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Komsta, Ł. (2023). Podstawy chemometrii. In R. Kocjan (Ed.), Chemia analityczna: podręcznik dla studentów. T. 2: Analiza instrumentalna (Wydanie III uaktualnione i rozszerzone). PZWL. https://doi.org/10.53271/2023.077
Gumieniczek, A. (Ed.). (2021). Wprowadzenie do analizy środków leczniczych (Wydanie I). PZWL.
Komsta, Ł., & Wicha-Komsta, K. (2018). Biological Background of Designer Drugs. In Chromatographic Techniques in the Forensic Analysis of Designer Drugs. CRC Press.
Komsta, Ł., Vander Heyden, Y., & Sherma, J. (Eds.). (2017). Chemometrics in Chromatography. CRC Press. https://doi.org/10.1201/9781315154404
Berecka, A., Gumieniczek, A., Kowalczuk, D., Skibiński, R., Komsta, Ł., Drozd, J., Inglot, T., Paw, B., Pomykalski, A., Pietraś, R., & Wydawnictwo Drukarnia Bestprint. (2016). Analiza chemiczna dla kosmetologów: praca zbiorowa. Best Print.
Gumieniczek, A. (Ed.). (2013). Analiza środków leczniczych: praca zbiorowa (Wyd. 2. popr. i zaktualizowane). Wydawnictwo, Drukarnia Best Print.
Komsta, Ł., Waksmundzka-Hajnos, M., & Sherma, J. (Eds.). (2013). Thin Layer Chromatography in Drug Analysis. CRC Press. https://doi.org/10.1201/b15637
Gumieniczek, A. (Ed.). (2009). Analiza środków leczniczych: praca zbiorowa. Wydawnictwo Drukarnia Best Print.
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Komsta, Ł., & Wicha-Komsta, K. (2024). Quantitative evaluation of dissolution profiles: From simple approaches to advanced chemometrics. Arhiv Za Farmaciju, 74(3), 105–117. https://doi.org/10.5937/arhfarm74-49757
Paw, B., Śliwa, R., Komsta, Ł., Senczyna, B., Karpińska, M., & Matysiak, J. (2024). Comparison of HPLC, HPTLC, and In Silico Lipophilicity Parameters Determined for 5-Heterocyclic 2-(2,4-Dihydroxyphenyl)-1,3,4-thiadiazoles. Molecules, 29(11), 2478. https://doi.org/10.3390/molecules29112478
Krasuska-Grzegorczyk, B., Komsta, Ł., & Danilczuk, Z. (2024). Effect of ACEA 1021 on Neurotoxicity Induced by Dexamethasone — Initial Behavioral Study. Acta Poloniae Pharmaceutica – Drug Research, 81(1), 167–174. https://doi.org/10.32383/appdr/185546
Gadowski, S., Tomiczak, K., Pietraś, R., & Komsta, Ł. (2023). Discriminant analysis of Gentiana headspace gas chromatography – mass spectrometry extract data from in vitro cultures. Acta Agrobotanica, 75. https://doi.org/10.5586/aa.7513
Gadowski, S., Tomiczak, K., & Komsta, Ł. (2023). High dynamic range in videodensitometry—a comparative study to classic videoscanning on Gentiana extracts. JPC – Journal of Planar Chromatography – Modern TLC, 36(1), 3–8. https://doi.org/10.1007/s00764-023-00226-3
Wróbel-Szkolak, J., Cwener, A., & Komsta, Ł. (2023). Novel Hyperspectral Analysis of Thin-Layer Chromatographic Plates—An Application to Fingerprinting of 70 Polish Grasses. Molecules, 28(9), 3745. https://doi.org/10.3390/molecules28093745
Wroński, M., Trawiński, J., Komsta, Ł., & Skibiński, R. (2023). Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC–MS Profiles of Maraviroc. Molecules, 28(3), 1195. https://doi.org/10.3390/molecules28031195
Wróbel-Szkolak, J., Cwener, A., Pietraś, R., & Komsta, Ł. (2022). Simultaneous component analysis as an interesting preliminary data analysis method in GC-MS – An example of headspace screening of Polish grasses. Acta Chromatographica, 1(aop). https://doi.org/10.1556/1326.2022.01099
Obradović, D., Komsta, Ł., Stavrianidi, A. N., Shpigun, O. A., Pokrovskiy, O. I., & Vujić, Z. (2022). Retention mechanisms of imidazoline and piperazine-related compounds in non-aqueous hydrophilic interaction and supercritical fluid chromatography based on chemometric design and analysis. Journal of Chromatography A, 1678, 463340. https://doi.org/10.1016/j.chroma.2022.463340
Wróbel-Szkolak, J., Cwener, A., & Komsta, Ł. (2022). Data fusion from several densitometric modes in fingerprinting of 70 grass species. JPC – Journal of Planar Chromatography – Modern TLC, 35(3), 287–297. https://doi.org/10.1007/s00764-022-00180-6
Filarowska-Jurko, J., Komsta, L., Smaga, I., Surowka, P., Marszalek-Grabska, M., Grochecki, P., Nizio, D., Filip, M., & Kotlinska, J. H. (2022). Maternal Separation Alters Ethanol Drinking and Reversal Learning Processes in Adolescent Rats: The Impact of Sex and Glycine Transporter Type 1 (GlyT1) Inhibitor. International Journal of Molecular Sciences, 23(10), 5350. https://doi.org/10.3390/ijms23105350
Gök, H. N., Luca, S. V., Ay, S. T., Komsta, Ł., Salmas, R. E., Orhan, I. E., & Skalicka-Woźniak, K. (2022). Profiling the annual change of the neurobiological and antioxidant effects of five Origanum species in correlation with their phytochemical composition. Food Chemistry, 368, 130775. https://doi.org/10.1016/j.foodchem.2021.130775
Gadowski, S., Tomiczak, K., & Komsta, Ł. (2021). Nonnegative principal component analysis in thin layer fingerprint screening: A case of Gentiana extracts from in vitro cultures. Journal of Liquid Chromatography & Related Technologies, 44(15–16), 820–828. https://doi.org/10.1080/10826076.2022.2089998
Dąbrowska, M., Starek, M., Chłoń-Rzepa, G., Zagórska, A., Komsta, Ł., Jankowska, A., Ślusarczyk, M., & Pawłowski, M. (2021). Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity. Bioorganic & Medicinal Chemistry Letters, 49, 128318. https://doi.org/10.1016/j.bmcl.2021.128318
Lopatynska-Mazurek, M., Komsta, L., Gibula-Tarlowska, E., & Kotlinska, J. H. (2021). Aversive Learning Deficits and Depressive-Like Behaviors Are Accompanied by an Increase in Oxidative Stress in a Rat Model of Fetal Alcohol Spectrum Disorders: The Protective Effect of Rapamycin. International Journal of Molecular Sciences, 22(13), 7083. https://doi.org/10.3390/ijms22137083
Komsta, Ł., Wicha-Komsta, K., & Kocki, T. (2021). Being Uncertain in Chromatographic Calibration—Some Unobvious Details in Experimental Design. Molecules, 26(22), 7035. https://doi.org/10.3390/molecules26227035
Wicha-Komsta, K., Skibiński, R., Kocki, T., Turski, W. A., & Komsta, Ł. (2021). HPLC Gradient Retention of Tryptophan and its Metabolites on Three Stationary Phases in Context of Lipophilicity Assessment. Journal of Chromatographic Science, 59(1), 40–46. https://doi.org/10.1093/chromsci/bmaa074
Klimek-Szczykutowicz, M., Szopa, A., Dziurka, M., Komsta, Ł., Tomczyk, M., & Ekiert, H. (2020). The Influence of Nasturtium officinale R. Br. Agar and Agitated Microshoot Culture Media on Glucosinolate and Phenolic Acid Production, and Antioxidant Activity. Biomolecules, 10(9), 1216. https://doi.org/10.3390/biom10091216
Szewczyk, K., Miazga-Karska, M., Pietrzak, W., Komsta, Ł., Krzemińska, B., & Grzywa-Celińska, A. (2020). Phenolic Composition and Skin-related Properties of the Aerial Parts Extract of Different Hemerocallis Cultivars. Antioxidants, 9(8), 690. https://doi.org/10.3390/antiox9080690
Szopa, A., Kubica, P., Komsta, Ł., Walkowicz-Bożek, A., & Ekiert, H. (2020). The effect of feeding culture media with biogenetic precursors on high production of depsides in agitated shoot cultures of black and red aronias. Plant Cell, Tissue and Organ Culture (PCTOC), 142(2), 379–399. https://doi.org/10.1007/s11240-020-01869-4
Wicha-Komsta, K., Skibiński, R., Kocki, T., Turski, W. A., & Komsta, Ł. (2020). Lipophilicity of tryptophan, its metabolites and derivatives measured by thin-layer chromatography. Journal of Liquid Chromatography & Related Technologies, 43(11–12), 375–380. https://doi.org/10.1080/10826076.2020.1725556
Zalewski, D. P., Ruszel, K. P., Stępniewski, A., Gałkowski, D., Bogucki, J., Komsta, Ł., Kołodziej, P., Chmiel, P., Zubilewicz, T., Feldo, M., Kocki, J., & Bogucka-Kocka, A. (2020). Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm. Journal of Clinical Medicine, 9(6), 1974. https://doi.org/10.3390/jcm9061974
Zalewski, D. P., Ruszel, K. P., Stępniewski, A., Gałkowski, D., Bogucki, J., Komsta, Ł., Kołodziej, P., Chmiel, P., Zubilewicz, T., Feldo, M., Kocki, J., & Bogucka-Kocka, A. (2020). Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease. Journal of Clinical Medicine, 9(5), 1251. https://doi.org/10.3390/jcm9051251
Obradović, D., Komsta, Ł., & Agbaba, D. (2020). Novel computational approaches to retention modeling in dual hydrophilic interactions/reversed phase chromatography. Journal of Chromatography A, 1619, 460951. https://doi.org/10.1016/j.chroma.2020.460951
Gajewska, K., Błażewicz, A., Laskowska, M., Niziński, P., Dymara – Konopka, W., & Komsta, Ł. (2020). Chemical elements and preeclampsia – An overview of current problems, challenges and significance of recent research. Journal of Trace Elements in Medicine and Biology, 59, 126468. https://doi.org/10.1016/j.jtemb.2020.126468
Hawrył, A., Hawrył, M., Hajnos-Stolarz, A., Abramek, J., Bogucka-Kocka, A., & Komsta, Ł. (2020). HPLC Fingerprint Analysis with the Antioxidant and Cytotoxic Activities of Selected Lichens Combined with the Chemometric Calculations. Molecules, 25(18), 4301. https://doi.org/10.3390/molecules25184301
Kubica, P., Szopa, A., Prokopiuk, B., Komsta, Ł., Pawłowska, B., & Ekiert, H. (2020). The influence of light quality on the production of bioactive metabolites – verbascoside, isoverbascoside and phenolic acids and the content of photosynthetic pigments in biomass of Verbena officinalis L. cultured in vitro. Journal of Photochemistry and Photobiology B: Biology, 203, 111768. https://doi.org/10.1016/j.jphotobiol.2019.111768
Bogucka-Kocka, A., Zalewski, D. P., Ruszel, K. P., Stępniewski, A., Gałkowski, D., Bogucki, J., Komsta, Ł., Kołodziej, P., Zubilewicz, T., Feldo, M., & Kocki, J. (2019). Dysregulation of MicroRNA Regulatory Network in Lower Extremities Arterial Disease. Frontiers in Genetics, 10. https://doi.org/10.3389/fgene.2019.01200
Krawczyk, R., Zubel, R., & Komsta, Ł. (2019). Military Training Areas and Vegetation – the Effect of Explosion Craters on Species Diversity along a Moisture Gradient. Polish Journal of Ecology, 67(3), 194–205. https://doi.org/10.3161/15052249PJE2019.67.3.003
Klimek-Szczykutowicz, M., Szopa, A., Blicharska, E., Dziurka, M., Komsta, Ł., & Ekiert, H. (2019). Bioaccumulation of selected macro- and microelements and their impact on antioxidant properties and accumulation of glucosinolates and phenolic acids in in vitro cultures of Nasturtium officinale (watercress) microshoots. Food Chemistry, 300, 125184. https://doi.org/10.1016/j.foodchem.2019.125184
Och, A., Zalewski, D., Komsta, Ł., Kołodziej, P., Kocki, J., & Bogucka-Kocka, A. (2019). Cytotoxic and Proapoptotic Activity of Sanguinarine, Berberine, and Extracts of Chelidonium majus L. and Berberis thunbergii DC. toward Hematopoietic Cancer Cell Lines. Toxins, 11(9), 485. https://doi.org/10.3390/toxins11090485
Komsta, Ł., Skibiński, R., Wróbel, J., Gadowski, S., & Skrzypiec, K. (2019). Experimental evaluation of solvent elution strength in reversed-phase TLC on medium polarity phases. Journal of Liquid Chromatography & Related Technologies, 42(9–10), 258–265. https://doi.org/10.1080/10826076.2019.1585610
Kozyra, M., Komsta, Ł., & Wojtanowski, K. (2019). Analysis of phenolic compounds and antioxidant activity of methanolic extracts from inflorescences of Carduus sp. Phytochemistry Letters, 31, 256–262. https://doi.org/10.1016/j.phytol.2019.04.012
Gawlik, M., Skibiński, R., & Komsta, Ł. (2019). Characterization of lacosamide metabolites by UHPLC–ESI–HRMS method. Acta Chromatographica, 32(2), 107–116. https://doi.org/10.1556/1326.2019.00591
Verey, M., & Komsta, Ł. (2018). Standardization of the notation dividing the ATPOL grid. Fragmenta Floristica et Geobotanica Polonica, 25, 107–111.
Komsta, Ł., Skibiński, R., Gadowski, S., Wróbel, J., & Skrzypiec, K. (2018). Experimental Evaluation of Solvent Elution Strength in Reversed-Phase Thin-Layer Chromatography on RP2 and RP8 Plates. JPC – Journal of Planar Chromatography – Modern TLC, 31(5), 351–354. https://doi.org/10.1556/1006.2018.31.5.1
Koch, W., Kukula-Koch, W., & Komsta, Ł. (2018). Correction: Koch, W., et al. Black Tea Samples Origin Discrimination Using Analytical Investigations of Secondary Metabolites, Antiradical Scavenging Activity and Chemometric Approach. Molecules 2018, 23, 513. Molecules, 23(9), 2093. https://doi.org/10.3390/molecules23092093
Koch, W., Kukula-Koch, W., Komsta, Ł., Marzec, Z., Szwerc, W., & Głowniak, K. (2018). Green Tea Quality Evaluation Based on Its Catechins and Metals Composition in Combination with Chemometric Analysis. Molecules, 23(7), 1689. https://doi.org/10.3390/molecules23071689
Skibiński, R., Trawiński, J., Komsta, Ł., & Murzec, D. (2018). Characterization of forced degradation products of toloxatone by LC-ESI-MS/MS. Saudi Pharmaceutical Journal, 26(4), 467–480. https://doi.org/10.1016/j.jsps.2018.02.012
Komsta, Ł. (2018). Being uncertain in thin layer chromatography—Some thoughts about latent details in the retention estimation. Journal of Liquid Chromatography & Related Technologies, 41(6), 309–314. https://doi.org/10.1080/10826076.2018.1448685
Koch, W., Kukula-Koch, W., & Komsta, Ł. (2018). Black Tea Samples Origin Discrimination Using Analytical Investigations of Secondary Metabolites, Antiradical Scavenging Activity and Chemometric Approach. Molecules, 23(3), 513. https://doi.org/10.3390/molecules23030513
Gawlik, M., Skibiński, R., Trawiński, J., & Komsta, Ł. (2018). Photocatalysis combined with chromatographic methods as a new promising tool in drug metabolism studies – a review. Acta Chromatographica, 30(1), 1–8. https://doi.org/10.1556/1326.2016.00202
Gawel, K., Jenda-Wojtanowska, M., Gibula-Bruzda, E., Kedzierska, E., Filarowska, J., Marszalek-Grabska, M., Wojtanowski, K. K., Komsta, L., Talarek, S., & Kotlinska, J. H. (2018). The influence of AMN082, metabotropic glutamate receptor 7 (mGlu7) allosteric agonist on the acute and chronic antinociceptive effects of morphine in the tail-immersion test in mice: Comparison with mGlu5 and mGlu2/3 ligands. Physiology & Behavior, 185, 112–120. https://doi.org/10.1016/j.physbeh.2017.12.035
Gumieniczek, A., Trębacz, H., Komsta, Ł., Atras, A., Jopa, B., Szumiło, M., & Popiołek, Ł. (2018). DSC, FT-IR, NIR, NIR-PCA and NIR-ANOVA for determination of chemical stability of diuretic drugs: impact of excipients. Open Chemistry, 16(1), 116–132. https://doi.org/10.1515/chem-2018-0014
Komsta, Ł., Dunin, U., & Skibiński, R. (2017). Can RP-8 plates be used in normal-phase systems? A chemometric approach to estimate the elution strength of popular solvents. JPC – Journal of Planar Chromatography – Modern TLC, 30(5), 401–404. https://doi.org/10.1556/1006.2017.30.5.9
Trawiński, J., Skibiński, R., & Komsta, Ł. (2017). Comparison of ESI and APCI sources in Q-TOF mass spectrometer in photodegradation study of selected psychotropic drugs. Acta Chromatographica, 29(2), 161–172. https://doi.org/10.1556/1326.2017.29.2.2
Wicha-Komsta, K., & Komsta, Ł. (2017). Unconventional TLC systems in lipophilicity determination: A review. Journal of Liquid Chromatography & Related Technologies, 40(5–6), 219–225. https://doi.org/10.1080/10826076.2017.1298023
Dąbrowska, M., Starek, M., Komsta, Ł., Szafrański, P., Stasiewicz-Urban, A., & Opoka, W. (2017). Assessment of the chromatographic lipophilicity of eight cephalosporins on different stationary phases. European Journal of Pharmaceutical Sciences, 101, 115–124. https://doi.org/10.1016/j.ejps.2017.01.034
Błażewicz, A., Liao, K.-Y., Liao, H.-H., Niziński, P., Komsta, Ł., Momčilović, B., Jabłońska-Czapla, M., Michalski, R., Prystupa, A., Sak, J. J., & Kocjan, R. (2017). Alterations of Hair and Nail Content of Selected Trace Elements in Nonoccupationally Exposed Patients with Chronic Depression from Different Geographical Regions. BioMed Research International, 2017, e3178784. https://doi.org/10.1155/2017/3178784
Komsta, Ł., Stępkowska, B., & Skibiński, R. (2017). The experimental design approach to eluotropic strength of 20 solvents in thin-layer chromatography on silica gel. Journal of Chromatography A, 1483, 138–141. https://doi.org/10.1016/j.chroma.2017.01.010
Selected conferences
(only abstract book data)
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FU65HJPN
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https://www.komsta.net/wp-content/plugins/zotpress/
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Zbornik sažetaka = Book of Abstracts: VI kongres farmaceuta Srbije sa međunarodnim učešćem, 15-19. oktobar 2014, Beograd : VI Serbian Congress of Pharmacy with International Participations, October 15th-19th, 2014, Belgrade. (2014). Savez farmaceutskih udruženja Srbije = Pharmaceutical Association of Serbia.
Chromatografia, niezbędne narzędzie w nauce i technice: X Konferencja Chromatograficzna, Lublin, 23-26 września 2014 r.: książka abstraktów. (2014). Uniwersytet Medyczny. Wydział Farmaceutyczny z Oddziałem Analityki Medycznej. Katedra i Zakład Chemii Leków.
Osiągnięcia w chemii leków: ogólnopolska konferencja naukowa, Poznań 6-7 września 2007 r. dla uczczenia 90. rocznicy urodzin profesora Ewarysta Pawełczyka, 70. rocznicy urodzin profesor Marianny Zając. (2007). Wydawnictwo Naukowe Uniwersytetu Medycznego im. Karola Marcinkowskiego.
Farmacja XXI wieku – wyzwania i nadzieje: XX Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego, Katowice-Spodek, 25-28 września 2007 : streszczenia. T. 2. (2007). s.n.
Nowoczesne techniki badawcze w ocenie jakości produktów leczniczych: Lublin, 21-22 września 2006: materiały sympozjum. (2006). Akademia Medyczna im. prof. Feliksa Skubiszewskiego. Wydział Farmaceutyczny. Katedra i Zakład Chemii Leków.
The application of chromatographic methods in phytochemical & biomedical analysis: 5th International Symposium on Chromatography of Natural Products (ISCNP), June, 19-22, 2006, Lublin (Poland) : abstracts. (2006). Medical University of Lublin.
Analityka w rozwoju cywilizacji: VII Polska Konferencja Chemii Analitycznej, [Toruń, 3-7.VII.2005]. (2005). SAR “Pomorze.”
XIX Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Farmacja – tradycja i nowoczesność, Wrocław 22-24 września 2004: streszczenia. T. 1 / [opracowanie redakcyjne: Jadwiga Biernat, Rafał Ilow, Dorota Haznar, Bożena Koralewicz] (Wydanie I). (2004). PTFarm.
The application of chromatographic methods in phytochemical & biomedical analysis: abstracts ; 4th International Symposium on Chromatography of Natural Products, June 14 – 17, 2004, Lublin – Kazimierz Dolny (Poland). (2004).
Kompleksowa ocena jakości substancji leczniczych i postaci leków: materiały konferencji naukowej, Poznań 18-19 września, 2003. (2003). Dział Wydawnictw Uczelnianych AM.
Advance in separation sciences on the day before the 100 years anniversary of chromatography discover: the abstract book of the 8th International Symposium on Separation Sciences, 8 – 12 September, 2002, Toruń (Poland) (1. ed). (2002). SAR Pomorze.